Wellcome Open Research (Nov 2023)
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK [version 2; peer review: 2 approved]
- Eleni Nastouli,
- Eleanor Barnes,
- Graham S. Cooke,
- Cori Campbell,
- Theresa Noble,
- David A. Smith,
- Steve Harris,
- Kinga A Várnai,
- Gail Roadknight,
- Hizni Salih,
- Ben Glampson,
- Stephanie Little,
- Dimitri Papadimitriou,
- Paul Klenerman,
- Luca Mercuri,
- Vince Taylor,
- Christopher R Jones,
- Hang Phan,
- Afzal Chaudhry,
- Josune Olza,
- Florina Borca,
- Luis Romão,
- Frazer Warricker,
- Louise English,
- David Ramlakhan,
- Monique I. Andersson,
- Salim I. Khakoo,
- Jane Collier,
- Philippa C. Matthews,
- Kerrie Woods,
- William Gelson,
- Tingyan Wang,
- Oliver Freeman,
- Jim Davies
Affiliations
- Eleni Nastouli
- Department of Clinical Virology, University College London Hospitals NHS Trust, London, UK
- Eleanor Barnes
- ORCiD
- Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Graham S. Cooke
- ORCiD
- NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK
- Cori Campbell
- ORCiD
- Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Theresa Noble
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- David A. Smith
- ORCiD
- NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
- Steve Harris
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Kinga A Várnai
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Gail Roadknight
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Hizni Salih
- ORCiD
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Ben Glampson
- NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK
- Stephanie Little
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Dimitri Papadimitriou
- NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK
- Paul Klenerman
- Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Luca Mercuri
- ORCiD
- NIHR Health Informatics Collaborative, Imperial College Healthcare NHS Trust, London, UK
- Vince Taylor
- Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Christopher R Jones
- Department of Infectious Disease, Imperial College London, London, UK
- Hang Phan
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- Afzal Chaudhry
- Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Josune Olza
- ORCiD
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- Florina Borca
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- Luis Romão
- ORCiD
- University College London Hospitals NHS Foundation Trust, London, UK
- Frazer Warricker
- University Hospital Southampton NHS Foundation Trust, Southampton, UK
- Louise English
- University College London Hospitals NHS Foundation Trust, London, UK
- David Ramlakhan
- University College London Hospitals NHS Foundation Trust, London, UK
- Monique I. Andersson
- ORCiD
- Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
- Salim I. Khakoo
- School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
- Jane Collier
- Department of Hepatology, John Radcliffe Hospital, Oxford, UK
- Philippa C. Matthews
- Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Kerrie Woods
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- William Gelson
- Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Tingyan Wang
- ORCiD
- Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Oliver Freeman
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Jim Davies
- NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
- Journal volume & issue
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Vol. 7
Abstract
Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load). Methods We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts. Results We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had ≥1 measurement annually, and the mean number of measurements per patient. Conclusions These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.
