Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

Xiang Gao; Meiling Wen; Yang Liu; Tian Hou; Meiwen An

Engineered Regeneration (Mar 2022)

Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

Xiang Gao,
Meiling Wen,
Yang Liu,
Tian Hou,
Meiwen An

Affiliations

Xiang Gao: Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan, Shanxi, 030024, China
Meiling Wen: Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan, Shanxi, 030024, China; Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Yang Liu: Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan, Shanxi, 030024, China; Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Tian Hou: Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan, Shanxi, 030024, China
Meiwen An: Institute of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan, Shanxi, 030024, China; Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Corresponding author at: Taiyuan University of Technology, China

Journal volume & issue: Vol. 3, no. 1
pp. 53 – 58

Abstract

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Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound site. The current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged regions. In our study, poly(L-lactide-co-caprolactone) (PLCL) was blended with polyurethane (PU) to obtain nanofibrous scaffolds via electrospinning. The electrospun fibers with 50% PLCL content had a certain number of intersections and jointing points, and exhibited significantly enhanced mechanical properties combined with suitable porosity. Moreover, cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes, indicating good cytocompatibility of composite scaffolds. These findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering.

Published in Engineered Regeneration

ISSN: 2666-1381 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Life
Website: https://www.keaipublishing.com/en/journals/engineered-regeneration/

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