Generation of an induced pluripotent stem cell line SMBCi010-A from a male with Multiple Osteochondroma carrying a EXT1 mutation

Yazhou Cui; Jing Wang; Genglin Zhang; Jing Luan; Jinxiang Han

Stem Cell Research (Jan 2021)

Generation of an induced pluripotent stem cell line SMBCi010-A from a male with Multiple Osteochondroma carrying a EXT1 mutation

Yazhou Cui,
Jing Wang,
Genglin Zhang,
Jing Luan,
Jinxiang Han

Affiliations

Yazhou Cui: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China
Jing Wang: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China
Genglin Zhang: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China
Jing Luan: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China
Jinxiang Han: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China; Corresponding author at: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China.

Journal volume & issue: Vol. 50
p. 102111

Abstract

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Multiple Osteochondroma is an abnormal skeleton development autosomal dominant genetic disease which caused by the mutation of EXT1 gene. In this study, we generated induced pluripotent stem cells (iPSCs) from the mesenchymal stem cells (MSCs) of a 12-year-old male patient by reprogramming MSCs with non-integrative vectors. The iPSCs line expresses pluripotent markers, has a normal male karyotype and can differentiate into the three germ layers.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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