Frontiers in Pharmacology (Jul 2021)

GLP-1 Receptor: A New Target for Sepsis

  • Fuxun Yang,
  • Fan Zeng,
  • Xiaoxiu Luo,
  • Yu Lei,
  • Jiajia Li,
  • Sen Lu,
  • Xiaobo Huang,
  • Yunping Lan,
  • Rongan Liu

DOI
https://doi.org/10.3389/fphar.2021.706908
Journal volume & issue
Vol. 12

Abstract

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Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.

Keywords