Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Apr 2000)
A comparison of hemodynamic effects of Midazolam and Thiopental in induction of anesthesia
Abstract
Objective: Although thiopental sodium (Nesdonal) is an almost ideal drug for induction of anesthesia, but it mostly cause hemodynamic changes such as hypotension. The objective of this study is to compare hemodynamic effects of thiopental sodium and Midazolam (From Benzodiazpine family) in order to replace it with thiopental when necessary. Methods: 50 patients in ASA I were divided into two groups (Each group 25 persons) randomly subjects in both groups were administered with premedication with an equal dose per patient’s weight. In first group anesthesia was started with thiopental sodium 4-5 mg/kg with succinylcholine and in the second group with Midazolam 0.25-0.3 mg/kg with succinylcholine and intubation was done after a given time. Heart rate and blood pressure were recorded for both groups at special times and data were compared with each other. Findings: In this study pulse rate of 20% of patients who received thiopental sodium were increased to 20 beats/min. It was 12% for Midazolam group the changes (P=0.000) were meaningful. An increase of systolic blood pressure more than 40 mmHg from base after intubation with thiopental sodium in 24% of persons (P=0.011) and 2 min after intubation in 20% persons (P=0.048) were meaningful. There were no such variations in Midazolam group. Data shows that any rise or fall in blood pressure and heart rate observed with thiopental sodium is more than that with Midazolam. Conclusion: Considering this research and the other studies show more record of hemodynamic condition of Midazolam than thiopental sodium. Therefore, in patients with dangerous hemodynamic variations, especially decreasing of blood pressure only induction with Midazolam or a combination of Midazolam and thiopental (For rapid onset action) as co-induction is useful.
