Nature Communications (Oct 2016)
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
- Anup Arumughan,
- Yvette Roske,
- Carolin Barth,
- Laura Lleras Forero,
- Kenny Bravo-Rodriguez,
- Alexandra Redel,
- Simona Kostova,
- Erik McShane,
- Robert Opitz,
- Katja Faelber,
- Kirstin Rau,
- Thorsten Mielke,
- Oliver Daumke,
- Matthias Selbach,
- Elsa Sanchez-Garcia,
- Oliver Rocks,
- Daniela Panáková,
- Udo Heinemann,
- Erich E. Wanker
Affiliations
- Anup Arumughan
- Max Delbrück Center for Molecular Medicine
- Yvette Roske
- Max Delbrück Center for Molecular Medicine
- Carolin Barth
- Max Delbrück Center for Molecular Medicine
- Laura Lleras Forero
- Max Delbrück Center for Molecular Medicine
- Kenny Bravo-Rodriguez
- Max-Planck-Institute for Coal Research
- Alexandra Redel
- Max Delbrück Center for Molecular Medicine
- Simona Kostova
- Max Delbrück Center for Molecular Medicine
- Erik McShane
- Max Delbrück Center for Molecular Medicine
- Robert Opitz
- Max Delbrück Center for Molecular Medicine
- Katja Faelber
- Max Delbrück Center for Molecular Medicine
- Kirstin Rau
- Max Delbrück Center for Molecular Medicine
- Thorsten Mielke
- Max Planck Institute for Molecular Genetics
- Oliver Daumke
- Max Delbrück Center for Molecular Medicine
- Matthias Selbach
- Max Delbrück Center for Molecular Medicine
- Elsa Sanchez-Garcia
- Max-Planck-Institute for Coal Research
- Oliver Rocks
- Max Delbrück Center for Molecular Medicine
- Daniela Panáková
- Max Delbrück Center for Molecular Medicine
- Udo Heinemann
- Max Delbrück Center for Molecular Medicine
- Erich E. Wanker
- Max Delbrück Center for Molecular Medicine
- DOI
- https://doi.org/10.1038/ncomms13047
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins on the disassembly of the p97 complex.
