Nature Communications (Jan 2020)
Targeting the tumor vasculature with engineered cystine-knot miniproteins
Abstract
Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for in vivo tumor vasculature imaging.