Comparison of pharmacokinetic parameters of oxytetracycline following single intravenous administration in goat, sheep and cattle calf

Abstract

The study was conducted to evaluate pharmacokinetics of oxytetracycline following single intravenous administration in goat sheep and cattle calves, and calculate the suitable dosages regimens. For this 15 animals were used 5 each of female goats, male sheep and male cattle calves in each species. Oxytetracycline hydrochloride solution was injected as a single dose (5 mg/kg) intravenous (i.v.) bolus administration. The analysis of plasma samples for oxytetracycline was done by HPLC. The OTC maintained its minimum ETC of 0.5 µg/ml up to 480 min in goat and sheep and 720 min in cattle calves after 5mg/kg body weight through intravenous administration, respectively. The pharmacokinetic parameters obtained in this study indicates that the OTC have wide distribution and longer residential time in body and maintained the therapeutic concentration in body.

Keywords

• Cattle calf
• Dosages regimens
• Goat
• Oxytetracycline
• Pharmacokinetics
• Sheep