Nature Communications (Jan 2016)
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion
- Yusuke Yamamoto,
- Xia Wang,
- Denis Bertrand,
- Florian Kern,
- Ting Zhang,
- Marcin Duleba,
- Supriya Srivastava,
- Chiea Chuen Khor,
- Yuanyu Hu,
- Lane H. Wilson,
- Hagen Blaszyk,
- Daniil Rolshud,
- Ming Teh,
- Jianjun Liu,
- Brooke E. Howitt,
- Matthew Vincent,
- Christopher P. Crum,
- Niranjan Nagarajan,
- Khek Yu Ho,
- Frank McKeon,
- Wa Xian
Affiliations
- Yusuke Yamamoto
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
- Xia Wang
- Department of Biology and Biochemistry, University of Houston
- Denis Bertrand
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Florian Kern
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Ting Zhang
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Marcin Duleba
- Department of Biology and Biochemistry, University of Houston
- Supriya Srivastava
- Department of Pathology, National University Heath System
- Chiea Chuen Khor
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Yuanyu Hu
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Lane H. Wilson
- Department of Genetics and Developmental Biology, University of Connecticut Health Center
- Hagen Blaszyk
- Digestive Health Center, Maine Medical Center
- Daniil Rolshud
- Digestive Health Center, Maine Medical Center
- Ming Teh
- Department of Pathology, National University Heath System
- Jianjun Liu
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Brooke E. Howitt
- Department of Pathology, Brigham and Women’s Hospital
- Matthew Vincent
- Ocata Therapeutics, Inc.
- Christopher P. Crum
- Department of Pathology, Brigham and Women’s Hospital
- Niranjan Nagarajan
- Department of Computational & Systems Biology, Genome Institute of Singapore, A-STAR
- Khek Yu Ho
- Department of Medicine, National University of Singapore
- Frank McKeon
- Department of Biology and Biochemistry, University of Houston
- Wa Xian
- Department of Pathology, Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/ncomms10380
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.
