Frontiers in Neurology (Oct 2023)
Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis
- Antonio Suppa,
- Antonio Suppa,
- Francesco Asci,
- Francesco Asci,
- Giovanni Costantini,
- Francesco Bove,
- Carla Piano,
- Francesca Pistoia,
- Francesca Pistoia,
- Rocco Cerroni,
- Livia Brusa,
- Valerio Cesarini,
- Sara Pietracupa,
- Sara Pietracupa,
- Nicola Modugno,
- Alessandro Zampogna,
- Patrizia Sucapane,
- Mariangela Pierantozzi,
- Tommaso Tufo,
- Tommaso Tufo,
- Antonio Pisani,
- Antonio Pisani,
- Antonella Peppe,
- Alessandro Stefani,
- Paolo Calabresi,
- Anna Rita Bentivoglio,
- Giovanni Saggio,
- Lazio DBS Study Group,
- Maria Concetta Altavista,
- Alessandra Calciulli,
- Marco Ciavarro,
- Francesca Cortese,
- Antonio Daniele,
- Alessandro De Biase,
- Manuela D'Ercole,
- Lazzaro Di Biase,
- Daniela Di Giuda,
- Pietro Di Leo,
- Danilo Genovese,
- Isabella Imbimbo,
- Alessandro Izzo,
- Rosa Liperoti,
- Giuseppe Marano,
- Massimo Marano,
- Marianna Mazza,
- Alessandra Monge,
- Nicola Montano,
- Michela Orsini,
- Leonardo Rigon,
- Marina Rizz,
- Camilla Rocchi,
- Gennaro Saporito,
- Laura Vacca,
- Fabio Viselli
Affiliations
- Antonio Suppa
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Antonio Suppa
- IRCCS Neuromed Institute, Pozzilli, IS, Italy
- Francesco Asci
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Francesco Asci
- IRCCS Neuromed Institute, Pozzilli, IS, Italy
- Giovanni Costantini
- Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy
- Francesco Bove
- Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Carla Piano
- Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Francesca Pistoia
- Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Coppito, AQ, Italy
- Francesca Pistoia
- Neurology Unit, San Salvatore Hospital, Coppito, AQ, Italy
- Rocco Cerroni
- Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
- Livia Brusa
- Neurology Unit, S. Eugenio Hospital, Rome, Italy
- Valerio Cesarini
- Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy
- Sara Pietracupa
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Sara Pietracupa
- IRCCS Neuromed Institute, Pozzilli, IS, Italy
- Nicola Modugno
- IRCCS Neuromed Institute, Pozzilli, IS, Italy
- Alessandro Zampogna
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Patrizia Sucapane
- Neurology Unit, San Salvatore Hospital, Coppito, AQ, Italy
- Mariangela Pierantozzi
- Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
- Tommaso Tufo
- Neurosurgery Unit, Policlinico A. Gemelli University Hospital Foundation IRCSS, Rome, Italy
- Tommaso Tufo
- 0Neurosurgery Department, Fakeeh University Hospital, Dubai, United Arab Emirates
- Antonio Pisani
- 1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
- Antonio Pisani
- 2IRCCS Mondino Foundation, Pavia, Italy
- Antonella Peppe
- 3IRCSS Fondazione Santa Lucia, Rome, Italy
- Alessandro Stefani
- Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
- Paolo Calabresi
- Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Anna Rita Bentivoglio
- Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
- Giovanni Saggio
- Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy
- Lazio DBS Study Group
- Maria Concetta Altavista
- Alessandra Calciulli
- Marco Ciavarro
- Francesca Cortese
- Antonio Daniele
- Alessandro De Biase
- Manuela D'Ercole
- Lazzaro Di Biase
- Daniela Di Giuda
- Pietro Di Leo
- Danilo Genovese
- Isabella Imbimbo
- Alessandro Izzo
- Rosa Liperoti
- Giuseppe Marano
- Massimo Marano
- Marianna Mazza
- Alessandra Monge
- Nicola Montano
- Michela Orsini
- Leonardo Rigon
- Marina Rizz
- Camilla Rocchi
- Gennaro Saporito
- Laura Vacca
- Fabio Viselli
- DOI
- https://doi.org/10.3389/fneur.2023.1267360
- Journal volume & issue
-
Vol. 14
Abstract
IntroductionDeep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS.Materials and methodsIn a cross-sectional study, we enrolled 108 controls and 101 patients with PD. The cohort of PD was divided into two groups: the first group included 50 patients with STN-DBS, and the second group included 51 patients receiving the best medical treatment. The voices were clinically evaluated using the Unified Parkinson's Disease Rating Scale part-III subitem for voice (UPDRS-III-v). We recorded and then analyzed voices using specific machine-learning algorithms. The likelihood ratio (LR) was also calculated as an objective measure for clinical-instrumental correlations.ResultsClinically, voice impairment was greater in STN-DBS patients than in those who received oral treatment. Using machine learning, we objectively and accurately distinguished between the voices of STN-DBS patients and those under oral treatments. We also found significant clinical-instrumental correlations since the greater the LRs, the higher the UPDRS-III-v scores.DiscussionSTN-DBS deteriorates speech in patients with PD, as objectively demonstrated by machine-learning voice analysis.
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