IL-1 stimulates ceramide accumulation without 
inducing apoptosis in intestinal epithelial cells

Fadia R. Homaidan; Marwan E. El-Sabban; Iman Chakroun; Mirvat El-Sibai; Ghassan S. Dbaibo

doi:10.1080/09629350210313

Mediators of Inflammation (Jan 2002)

IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells

Fadia R. Homaidan,
Marwan E. El-Sabban,
Iman Chakroun,
Mirvat El-Sibai,
Ghassan S. Dbaibo

Affiliations

Fadia R. Homaidan: Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Marwan E. El-Sabban: Department of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Iman Chakroun: Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Mirvat El-Sibai: Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Ghassan S. Dbaibo: Department of Pediatrics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

DOI: https://doi.org/10.1080/09629350210313
Journal volume & issue: Vol. 11, no. 1
pp. 39 – 45

Abstract

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Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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