International Journal of Nanomedicine (Sep 2019)

Thyroid cancer MR molecular imaging via SHP2-targeted nanoparticles

  • Hu Z,
  • Qin J,
  • Li T,
  • Guo J

Journal volume & issue
Vol. Volume 14
pp. 7365 – 7373

Abstract

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ZhongQian Hu,1 JiaLe Qin,2 TianKuan Li,1 JinHe Guo3 1Department of Ultrasound, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of China; 2Department of Ultrasound, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, People’s Republic of China; 3Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, People’s Republic of ChinaCorrespondence: TianKuan LiDepartment of Ultrasound, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 5402Email [email protected] GuoCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, People’s Republic of ChinaTel +86 25 8327 2114Email [email protected]: Molecular imaging has generated a great demand to develop targeted contrast agents for MR imaging.Materials and methods: In this study, we synthesized Src homology 2-containing phosphotyrosine phosphatase 2 (SHP2)-targeted and polylactic-co-glycolic acid–-based nanoparticles (NPs), which encapsulated perfluoropentane and being chelated with gadolinium (Gd3+) as an efficient molecular probe for targeting MR imaging on thyroid carcinoma.Results: These NPs displayed practical properties and favorable biocompatibility in vitro. Furthermore, they showed abilities to specifically target thyroid cancer and enhance MRI as a contrast agent in both in vitro and in vivo experiments.Conclusion: This novel MR molecular imaging based on this SHP2-targeted contrast agent provides a useful and non-invasive method for the early detection of thyroid carcinoma.Keywords: thyroid tumor, SHP2, Gd3+, nanoparticles, MR molecular imaging

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