Nature Communications (Feb 2019)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
- Takayoshi Sasako,
- Mitsuru Ohsugi,
- Naoto Kubota,
- Shinsuke Itoh,
- Yukiko Okazaki,
- Ai Terai,
- Tetsuya Kubota,
- Satoshi Yamashita,
- Kunio Nakatsukasa,
- Takumi Kamura,
- Kaito Iwayama,
- Kumpei Tokuyama,
- Hiroshi Kiyonari,
- Yasuhide Furuta,
- Junji Shibahara,
- Masashi Fukayama,
- Kenichiro Enooku,
- Kazuya Okushin,
- Takeya Tsutsumi,
- Ryosuke Tateishi,
- Kazuyuki Tobe,
- Hiroshi Asahara,
- Kazuhiko Koike,
- Takashi Kadowaki,
- Kohjiro Ueki
Affiliations
- Takayoshi Sasako
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Mitsuru Ohsugi
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Naoto Kubota
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Shinsuke Itoh
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Yukiko Okazaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Ai Terai
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Tetsuya Kubota
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Satoshi Yamashita
- Department of Systems BioMedicine, Tokyo Medical and Dental University
- Kunio Nakatsukasa
- Division of Biological Sciences, Graduate School of Science, Nagoya University
- Takumi Kamura
- Division of Biological Sciences, Graduate School of Science, Nagoya University
- Kaito Iwayama
- Graduate School of Comprehensive Human Science, University of Tsukuba
- Kumpei Tokuyama
- Graduate School of Comprehensive Human Science, University of Tsukuba
- Hiroshi Kiyonari
- Animal Resource Development Unit, RIKEN Center for Life Science Technologies
- Yasuhide Furuta
- Animal Resource Development Unit, RIKEN Center for Life Science Technologies
- Junji Shibahara
- Department of Pathology, Graduate School of Medicine, The University of Tokyo
- Masashi Fukayama
- Department of Pathology, Graduate School of Medicine, The University of Tokyo
- Kenichiro Enooku
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Kazuya Okushin
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Takeya Tsutsumi
- Department of Infectious Disease, Graduate School of Medicine, The University of Tokyo
- Ryosuke Tateishi
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Kazuyuki Tobe
- The First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences of Research, The University of Toyama
- Hiroshi Asahara
- Department of Systems BioMedicine, Tokyo Medical and Dental University
- Kazuhiko Koike
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
- Takashi Kadowaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Kohjiro Ueki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-019-08591-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans.
