Skeletal Editing of Heterocycles – A New Tool for Lead Exploration?

Abstract

Many new methods for single atom skeletal editing of heterocycles have been developed in the past few years with obvious applications to discovery chemistry. In this perspective, we assess the recent advances in this field and the potential application to lead exploration campaigns.

Keywords

• Heterocyclic chemistry
• Lead Exploration
• Medicinal chemistry
• Skeletal editing
• Synthesis