In Silico Study of Plant Polyphenols' Interactions with VP24–Ebola Virus Matrix Protein

Abstract

The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6–tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies.

Keywords

• Ebola virus
• VP24
• KPNA5
• STAT1
• plant polyphenols
• molecular docking