Solubility; still a challenging subject in pharmaceutical sciences

Abstract

Solubility of a drug/drug candidate is one of the most important required physico-chemical properties in pharmaceutical area and nearly 40% of drug candidates fail to proceed to the higher trial phases of new drug development process because of their poor solubility. The commonly used method is to determine the experimental values of either thermodynamic or kinetic solubility. Numerous efforts were made to develop predictive tools for replacing the time consuming and costly experimental methods.