Nature Communications (Oct 2018)

The olfactory epithelium as a port of entry in neonatal neurolisteriosis

  • Dennis Pägelow,
  • Chintan Chhatbar,
  • Andreas Beineke,
  • Xiaokun Liu,
  • Andreas Nerlich,
  • Kira van Vorst,
  • Manfred Rohde,
  • Ulrich Kalinke,
  • Reinhold Förster,
  • Stephan Halle,
  • Peter Valentin-Weigand,
  • Mathias W. Hornef,
  • Marcus Fulde

DOI
https://doi.org/10.1038/s41467-018-06668-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Listeria monocytogenes causes meningitis in newborns. Here, Pägelow et al. present a mouse model of neonatal cerebral listeriosis, and show that nasal inoculation, but not intragastric administration, leads to early brain infection in the absence of bacteraemia during the neonatal period.