Frontiers in Pharmacology (Jun 2018)

Sitagliptin and Fractures in Type 2 Diabetes: A Nationwide Population-Based Propensity-Matching Study

  • Shih-Yi Lin,
  • Shih-Yi Lin,
  • Wu-Huei Hsu,
  • Wu-Huei Hsu,
  • Cheng-Chieh Lin,
  • Cheng-Chieh Lin,
  • Cheng-Li Lin,
  • Cheng-Li Lin,
  • Chun-Hao Tsai,
  • Chun-Hao Tsai,
  • Hung-Chieh Yeh,
  • Chung-Y. Hsu,
  • Chia-Hung Kao,
  • Chia-Hung Kao,
  • Chia-Hung Kao

DOI
https://doi.org/10.3389/fphar.2018.00677
Journal volume & issue
Vol. 9

Abstract

Read online

Background: Sitagliptin, a dipeptidyl peptidase-4 inhibitor possibly affects bone turnover. We conducted this cohort study to determine whether sitagliptin is associated with an increased risk of fracture.Methods: The sitagliptin cohort included 1,578 patients aged 20 years and above. The nonsitagliptin cohort comprised propensity-score matched patients at a ratio of 1:1. The primary outcome was the incidence of fractures, which was evaluated using Kaplan–Meier survival analysis and proportional hazards modeling.Results: The mean age of patients in the sitagliptin and nonsitagliptin cohorts was 63.1 and 63.3 years, respectively. The incidence of fractures in the sitagliptin cohort was 46 per 1,000 person-years and that in the nonsitagliptin cohort was 40.8 per 1,000 person-years. Compared with patients in the nonsitagliptin cohort, those in the sitagliptin cohort who received sitagliptin for ≥250 days had a higher risk of fracture (aHR = 1.32, 95% CI = 1.06–1.64).Conclusion: Using sitaglipin ≥250 days was associated with an increased risk of fracture.

Keywords