Nature Communications (Jun 2017)

A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

  • Zhiyuan Hu,
  • Christopher Yau,
  • Ahmed Ashour Ahmed

DOI
https://doi.org/10.1038/ncomms15943
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.