Nature Communications (Jun 2017)
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
Abstract
Nonsense-mediated decay (NMD) eliminates transcripts with premature stop codons and has been linked to cancer genesis. Here, the authors develop an algorithm to predict NMD and perform a pan-cancer analysis that finds that some hypermutated cancers are dependent on mutations that elicit NMD.