Y-Branched Titanium Dioxide Nanotubes as a Potential Antimicrobial Coating for Implants
Angela Gabriela Păun,
Valeria Petrina,
Nicoleta Badea,
Camelia Ungureanu,
Simona Popescu,
Cristina Dumitriu
Affiliations
Angela Gabriela Păun
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
Valeria Petrina
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
Nicoleta Badea
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
Camelia Ungureanu
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
Simona Popescu
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
Cristina Dumitriu
Faculty of Chemical Engineering and Biotechnologies, The National University of Science and Technology Politehnica Bucharest, Gh. Polizu 1–7, 011061 Bucharest, Romania
The early loss of dental implants can be avoided with systemic antibiotics, however there are potentially significant side effects. Consequently, the use of local drug administration techniques is necessary to make dental implant therapy more practical. In this study, Y-branched nanotubes were prepared by non-expensive and simple anodization in two steps. Tests were performed to highlight their potential for local antibiotic administration. Y-branched nanotubes were able to incorporate a dose of Tetracycline and ensure its electrochemical stability. The presence of tetracycline significantly enhanced antibacterial efficacy, resulting in an increase of up to 55% for Escherichia coli and Pseudomonas aeruginosa and 50% for Staphylococcus aureus. The comparable antibacterial effects of the nanostructured surfaces highlight the potential of tetracycline in promoting antimicrobial action. Moreover, the addition of tetracycline does not influence the structural, morphological and stability properties of the nanostructured deposited TiO2 films.
