Intrachromosomal regulation decay in breast cancer

Abstract

Biological systems exhibit unique phenotypes as the result of the expression of a genomic program. The regulation of this program is a complex phenomenon, wherein different regulatory mechanisms are involved. The deregulation of this program is at the centre of the emergence of diseases such as breast cancer. In particular, it has been observed that coregulation patterns between physically distant genes are lost in breast cancer.

Keywords

• genomic regulation
• information theory
• cancer
• decay of correlations
• 60-08
• 62b10
• 93a30