Nature Communications (Sep 2018)
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
- Steven Offenbacher,
- Yizu Jiao,
- Steven J. Kim,
- Julie Marchesan,
- Kevin L. Moss,
- Li Jing,
- Kimon Divaris,
- Sompop Bencharit,
- Cary S. Agler,
- Thiago Morelli,
- Shaoping Zhang,
- Lu Sun,
- William T. Seaman,
- Dale Cowley,
- Silvana P. Barros,
- James D. Beck,
- Matthias Munz,
- Arne S. Schaefer,
- Kari E. North
Affiliations
- Steven Offenbacher
- Department of Periodontology, School of Dentistry, University of North Carolina
- Yizu Jiao
- Department of Periodontology, School of Dentistry, University of North Carolina
- Steven J. Kim
- Department of Periodontology, School of Dentistry, University of North Carolina
- Julie Marchesan
- Department of Periodontology, School of Dentistry, University of North Carolina
- Kevin L. Moss
- Department of Dental Ecology, School of Dentistry, University of North Carolina
- Li Jing
- Department of Periodontology, School of Dentistry, University of North Carolina
- Kimon Divaris
- Department of Pediatric Dentistry, School of Dentistry, University of North Carolina
- Sompop Bencharit
- Department of General Practice, School of Dentistry, Virginia Commonwealth University
- Cary S. Agler
- Oral and Craniofacial Health Sciences, School of Dentistry, University of North Carolina
- Thiago Morelli
- Department of Periodontology, School of Dentistry, University of North Carolina
- Shaoping Zhang
- Department of Periodontology, School of Dentistry, University of North Carolina
- Lu Sun
- Department of Periodontology, School of Dentistry, University of North Carolina
- William T. Seaman
- Lineberger Comprehensive Cancer Center, University of North Carolina
- Dale Cowley
- UNC Animal Models Core, University of North Carolina
- Silvana P. Barros
- Department of Periodontology, School of Dentistry, University of North Carolina
- James D. Beck
- Department of Dental Ecology, School of Dentistry, University of North Carolina
- Matthias Munz
- Department of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin
- Arne S. Schaefer
- Department of Periodontology, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-018-05940-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.
