NKG2A is a NK cell exhaustion checkpoint for HCV persistence

Chao Zhang; Xiao-mei Wang; Shu-ran Li; Trix Twelkmeyer; Wei-hong Wang; Sheng-yuan Zhang; Shu-feng Wang; Ji-zheng Chen; Xia Jin; Yu-zhang Wu; Xin-wen Chen; Sheng-dian Wang; Jun-qi Niu; Hai-rong Chen; Hong Tang

doi:10.1038/s41467-019-09212-y

Nature Communications (Apr 2019)

NKG2A is a NK cell exhaustion checkpoint for HCV persistence

Chao Zhang,
Xiao-mei Wang,
Shu-ran Li,
Trix Twelkmeyer,
Wei-hong Wang,
Sheng-yuan Zhang,
Shu-feng Wang,
Ji-zheng Chen,
Xia Jin,
Yu-zhang Wu,
Xin-wen Chen,
Sheng-dian Wang,
Jun-qi Niu,
Hai-rong Chen,
Hong Tang

Affiliations

Chao Zhang: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Xiao-mei Wang: Department of Hepatology, The First Hospital of Jilin University
Shu-ran Li: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Trix Twelkmeyer: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Wei-hong Wang: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Sheng-yuan Zhang: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Shu-feng Wang: Institute of Immunology, The Third Military Medical University
Ji-zheng Chen: The State Key Laboratory of Virology and Center for Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences
Xia Jin: The Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yu-zhang Wu: Institute of Immunology, The Third Military Medical University
Xin-wen Chen: The State Key Laboratory of Virology and Center for Viral Pathology, Wuhan Institute of Virology, Chinese Academy of Sciences
Sheng-dian Wang: The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Jun-qi Niu: Department of Hepatology, The First Hospital of Jilin University
Hai-rong Chen: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences
Hong Tang: The Joint Laboratory of Infection and Immunity at Institut Pasteur of Shanghai and Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-09212-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Immune cells may become less responsive, or ‘exhausted’, upon chronic viral infection, but the underlying mechanism and crosstalk are still unclear. Here the authors show that, upon chronic hepatitis C virus (HCV) infection, natural killer cell exhaustion is induced by NKG2A signalling to instruct downstream exhaustion of CD8+ T cells and HCV persistence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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