High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Elodie Bousquet, MD, PhD; Camille Chenevier-Gobeaux, MD; Thara Jaworski; Héloïse Torres-Villaros, MD; Marta Zola, MD; Irmela Mantel, MD; Laura Kowalczuk, PhD; Alexandre Matet, MD, PhD; Alejandra Daruich, MD, PhD; Min Zhao, MD, PhD; Suzanne Yzer, MD; Francine Behar-Cohen, MD, PhD

Ophthalmology Science (Sep 2023)

High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Elodie Bousquet, MD, PhD,
Camille Chenevier-Gobeaux, MD,
Thara Jaworski,
Héloïse Torres-Villaros, MD,
Marta Zola, MD,
Irmela Mantel, MD,
Laura Kowalczuk, PhD,
Alexandre Matet, MD, PhD,
Alejandra Daruich, MD, PhD,
Min Zhao, MD, PhD,
Suzanne Yzer, MD,
Francine Behar-Cohen, MD, PhD

Affiliations

Elodie Bousquet, MD, PhD: Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France
Camille Chenevier-Gobeaux, MD: Service de diagnostic biologique automatisé, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France
Thara Jaworski: Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France
Héloïse Torres-Villaros, MD: Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France
Marta Zola, MD: Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France
Irmela Mantel, MD: Department of Ophthalmology, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Switzerland
Laura Kowalczuk, PhD: Department of Ophthalmology, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Switzerland
Alexandre Matet, MD, PhD: Department of Ophthalmology, Institut Curie, University of Paris Cité, Paris, France
Alejandra Daruich, MD, PhD: Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France; Department of Ophthalmology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France
Min Zhao, MD, PhD: Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France
Suzanne Yzer, MD: Department of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the Netherlands
Francine Behar-Cohen, MD, PhD: Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France; Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France; Correspondence: Francine Behar-Cohen, MD, PhD, centre de recherche des cordeliers, 15 rue de l’école de médecine, 75006 Paris, France.

Journal volume & issue: Vol. 3, no. 3
p. 100278

Abstract

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Purpose: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein. Design: Cross-sectional multicenter study. Participants: Patients with CSCR compared with age- and sex-matched healthy participants. Methods: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum. Main Outcome Measures: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants. Results: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR. Conclusions: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

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