Фундаментальная и клиническая медицина (Jun 2018)
FASCIOLA HEPATICA: MORPHOMETRIC ANALYSIS OF EGGS AFTER TRICLABENDAZOLE TREATMENT
Abstract
Aim. To evaluate effects of triclabendazole on the egg production by Fasciola hepatica. Materials and Methods. Fasciola hepatica were isolated from the liver of spontaneously invaded sheep after the administration of triclabendazole (10 mg/kg). Control animals did not receive anthelmintics. Efficacy of triclabendazole was assessed using the morphometric analysis of the eggs (n = 50). Results. Administration of triclabendazole led to the increase in total egg size as compared to control animals (9.15∙10-8 ± 0,06 mm3 and 8,1∙10-8 ± 0,71 mm3, respectively, p = 0,002) and their content (6.98∙10-8±0,04 mm3 and 5,3∙10-8±0,12 mm3, respectively, p = 0,0001) suggestive of increased permeability of the shell and swelling of the eggs. Total size of eggs to size of their contents was 1:0,77 compared to 1:0,65 in control animals (p = 0,0001) that indicated egg degeneration. Conclusion. Triclabendazole at a dose of 10 mg/kg causes degeneration of Fasciola hepatics eggs and leads to cessation of their development.
