Catalytic asymmetric Nakamura reaction by gold(I)/chiral N,Nʹ-dioxide-indium(III) or nickel(II) synergistic catalysis

Abstract

Although enols and enolates addition to unactivated alkynes is used for carbon-carbon bond modification a catalytic asymmetric alkyne with 1,3-dicarbonyl compound has been elusive. Here, the authors achieve this using the synergistic activation of chiral N,N′-dioxide-indium(III) or nickel(II) Lewis acid and achiral gold(I) π-acid.”