Research progress on solid stress in tumors

Abstract

In recent decades， tumor microenvironment （TME） plays a significant role in tumorigenesis， progression， immune evasion， and therapeutic response， which has become a hot topic in tumor research. As a physical feature of TME， “solid stress” can be applied from the outside by surrounding normal tissues or caused by the tumor itself due to its growth. As the tumor grows， solid stress will destroy the structure and function of surrounding tissues through biochemical-physical mechanisms and promote tumor occurrence and treatment resistance. In this article， the mechanism and related progress on solid stress in tumors were reviewed and the association between cancer biology and physics was investigated， aiming to provide reference for the research and development of new drugs and treatment strategies for cancer.

Keywords

• |solid stress|tumor microenvironment|biomechanics|mechanical stimulation|mechanical signal transduction