Antibacterial Evaluation of Some Schiff Bases Derived from 2-Acetylpyridine and Their Metal Complexes

Abstract

A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), <em>Acinetobacter baumanni</em> (AC), <em>Klebsiella pneumonie</em> (KB) and <em>Pseudomonas aeruginosa</em> (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against <em>A. baumanii</em> and <em>P. aeruginosa</em>.

Keywords

• Schiff bases
• metal complexes
• x-ray crystallography
• anti-bacteria