Effect of DMPA on IL-1 Alpha in Serum of Women with Endometrioma

Abstract

Objective: To study the effect of DMPA on serum IL-1α in women with endometrioma undergoing the conservative surgery.Materials and methods:A randomized clinical trial was performed in thirty-five women with endometrioma who underwent conservative surgery in Reproductive Endocrinology and Laparoscopy clinic in Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital. These patients were randomly assigned to one of the following treatments: group A surgery and postoperative treatment with DMPA 150 mg intramuscular or group B surgery alone. Serum IL-1α level was measured by enzyme-linked immunosorbent assay (ELISA) in both groups. Pain scores were evaluated using a visual analog scale (VAS) at 2 and 12 weeks after the operation.Results: There was no significant difference in IL-1α serum levels between both groups at 2 weeks and 12 weeks after the surgery (p = 0.06 and 0.86 respectively). There was no significant difference in pre and postoperative IL-1α level between both group (p = 0.23 and 1.00 respectively). Pain scores of both groups were significantly decreased at 2 weeks and 12 weeks after the surgery (p < 0.001). The patients in DMPA group had significantly less pain scores at 12 weeks after the surgery (p = 0.01). Conclusion: The current study demonstrated that no significant change of IL-1α serum level in women with endometrioma before and after the surgery, with or without postoperative treatment with DMPA. We found decreasing of pain score in both group after surgery and less pain score in DMPA group.

Keywords

• endometriosis
• endometrioma
• conservative surgery
• IL-1α
• DMPA