Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

Julia Ramírez; Stefan van Duijvenboden; Ioanna Ntalla; Borbala Mifsud; Helen R Warren; Evan Tzanis; Michele Orini; Andrew Tinker; Pier D. Lambiase; Patricia B. Munroe

doi:10.1038/s41467-018-04148-1

Nature Communications (May 2018)

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

Julia Ramírez,
Stefan van Duijvenboden,
Ioanna Ntalla,
Borbala Mifsud,
Helen R Warren,
Evan Tzanis,
Michele Orini,
Andrew Tinker,
Pier D. Lambiase,
Patricia B. Munroe

Affiliations

Julia Ramírez: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Stefan van Duijvenboden: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Ioanna Ntalla: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Borbala Mifsud: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Helen R Warren: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Evan Tzanis: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Michele Orini: Barts Heart Centre, St Bartholomews Hospital
Andrew Tinker: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Pier D. Lambiase: Institute of Cardiovascular Science, University College London
Patricia B. Munroe: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London

DOI: https://doi.org/10.1038/s41467-018-04148-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Genome-wide association studies have identified multiple loci for resting heart rate (HR) but the genetic factors associated with HR increase during and HR recovery after exercise are less well studied. Here, the authors examine both traits in a two-stage GWAS design in up to 67,257 individuals from UK Biobank.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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