Nature Communications (Jul 2021)
S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis
- Meng-Lin Chao,
- Shanshan Luo,
- Chao Zhang,
- Xuechun Zhou,
- Miao Zhou,
- Junyan Wang,
- Chuiyu Kong,
- Jiyu Chen,
- Zhe Lin,
- Xin Tang,
- Shixiu Sun,
- Xinlong Tang,
- Hongshan Chen,
- Hong Wang,
- Dongjin Wang,
- Jin-Peng Sun,
- Yi Han,
- Liping Xie,
- Yong Ji
Affiliations
- Meng-Lin Chao
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Shanshan Luo
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Chao Zhang
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Xuechun Zhou
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Miao Zhou
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Junyan Wang
- Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo college of Medicine, Shandong University
- Chuiyu Kong
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Jiyu Chen
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Zhe Lin
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Xin Tang
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Shixiu Sun
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Xinlong Tang
- Department of Thoracic and Cardiovascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School
- Hongshan Chen
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Hong Wang
- The Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine
- Dongjin Wang
- Department of Thoracic and Cardiovascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School
- Jin-Peng Sun
- Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo college of Medicine, Shandong University
- Yi Han
- Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University
- Liping Xie
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- Yong Ji
- Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-021-24736-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diabetes-accelerated atherosclerosis.
