Progress in research on connexin 43 in oral squamous cell carcinoma

Abstract

Cell gap junctions are a universal form of cellular connection in animal tissue that mediate the exchange of information，energy and material between adjacent cells. Clinical studies have demonstrated that the abnormal ex⁃ pression of the connexin 43（Cx43）gene is closely associated with carcinogenesis and tumor progression. The present study reviewed relevant studies concerning the association between abnormal expression of Cx43 and oral squamous cell carcinoma as well as communication abnormalities of cell gap junctions.

Keywords

• Oral squamous cell carcinoma，
• Cx43，
• Gap junction intercellular communication，
• Tongue squamous cell carcinom，
• Phosphorylation，