Communications Biology (Oct 2021)

Functional characterization of a bioengineered liver after heterotopic implantation in pigs

  • Brett D. Anderson,
  • Erek D. Nelson,
  • DongJin Joo,
  • Bruce P. Amiot,
  • Aleksandr A. Katane,
  • Alyssa Mendenhall,
  • Benjamin G. Steiner,
  • Aron R. Stumbras,
  • Victoria L. Nelson,
  • R. Noelle Palumbo,
  • Thomas W. Gilbert,
  • Dominique S. Davidow,
  • Jeffrey J. Ross,
  • Scott L. Nyberg

DOI
https://doi.org/10.1038/s42003-021-02665-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size for humans.