Insights into the temperature and concentration dependent studies of the Anti-diabetic drug in aqueous binary and ternary (water +sucrose) mixtures at body temperature

Abstract

Thermodynamic and compressibility studies together with biological studies play an important role in the effective design and development of drug. In the current study, various drug-molecular interactions have been studied from thermophysical properties. The experimental density(ρ) and speed of sound(u) measurements for anti-diabetic drug Metformin hydrochloride (M.HCl) in binary as well as in ternary mixtures have been reported within the concentration range of 0.03–0.15 mol.kg−1 at various temperatures (305.15, 310.15 and 315.15 K) and atmospheric pressure. Various parameters like apparent molar volume of solute (Vϕ) and apparent molar compressibility of solute (KS,ϕ), limiting apparent molar volume of solute (Vϕ0), limiting apparent molar compressibility of solute (KS,ϕ0) and hydration number (nh) have been measured for binary (M.HCl + water) as well as ternary (M.HCl + Sucrose + Water) systems systematically using the experimentally measured ρ and u data. Further transfer volume (ΔtrVϕ0) of M.HCl from water to aqueous sucrose solutions have been measured at different temperatures. The hydration behavior of M.HCl has been understood from the obtained values of hydration number for studied systems at various temperatures. All the experimental results have been analysed in the light of various interactions among molecules of solvent and solute respectively.

Keywords

• Metformin hydrochloride
• Sucrose
• Apparent molar volume
• Apparent molar compressibility
• Hydration number