Positive Correlation between Relative Concentration of Spermine to Spermidine in Whole Blood and Skeletal Muscle Mass Index: A Possible Indicator of Sarcopenia and Prognosis of Hemodialysis Patients
Hidenori Sanayama,
Kiyonori Ito,
Susumu Ookawara,
Takeshi Uemura,
Sojiro Imai,
Satoshi Kiryu,
Miho Iguchi,
Yoshio Sakiyama,
Hitoshi Sugawara,
Yoshiyuki Morishita,
Kaoru Tabei,
Kazuei Igarashi,
Kuniyasu Soda
Affiliations
Hidenori Sanayama
Division of Neurology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Kiyonori Ito
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Susumu Ookawara
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Takeshi Uemura
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Josai University, Saitama 330-0295, Japan
Sojiro Imai
Department of Dialysis, Minami-Uonuma City Hospital, Niigata 949-6680, Japan
Satoshi Kiryu
Department of Dialysis, Minami-Uonuma City Hospital, Niigata 949-6680, Japan
Miho Iguchi
Department of Dialysis, Minami-Uonuma City Hospital, Niigata 949-6680, Japan
Yoshio Sakiyama
Division of Neurology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Hitoshi Sugawara
Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Yoshiyuki Morishita
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Kaoru Tabei
Department of Dialysis, Minami-Uonuma City Hospital, Niigata 949-6680, Japan
Kazuei Igarashi
Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba 260-0856, Japan
Kuniyasu Soda
Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan
Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal failure. Hemodialysis (HD) may compensate for polyamine excretion; however, little is known about polyamine excretion. We measured whole-blood polyamine levels in patients on HD and examined the relationship between polyamine concentrations and indicators associated with health status. Study participants were 59 hemodialysis patients (median age: 70.0 years) at Minami-Uonuma City Hospital and 26 healthy volunteers (median age: 44.5 years). Whole-blood spermidine levels were higher and spermine/spermidine ratio (SPM/SPD) was lower in hemodialysis patients. Hemodialysis showed SPD efflux into the dialysate; however, blood polyamine levels were not altered by hemodialysis and appeared to be minimally excreted. The skeletal muscle mass index (SMI), which was positively correlated with hand grip strength and serum albumin level, was positively correlated with SPM/SPD. Given that sarcopenia and low serum albumin levels are reported risk factors for poor prognosis in HD patients, whole blood SPM/SPD in hemodialysis patients may be a new indicator of the prognosis and health status of HD patients.
