Nature Communications (Jul 2018)

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

  • Sang-Min Jang,
  • Ya Zhang,
  • Koichi Utani,
  • Haiqing Fu,
  • Christophe E. Redon,
  • Anna B. Marks,
  • Owen K. Smith,
  • Catherine J. Redmond,
  • Adrian M. Baris,
  • Danielle A. Tulchinsky,
  • Mirit I. Aladjem

DOI
https://doi.org/10.1038/s41467-018-05177-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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RepID has previously been shown to promote origin firing. Here the authors reveal that RepID regulates replication origins via the recruitment of the CRL4 complex, and prevents re-initiation and unscheduled DNA replication.