Tryptase and Chymase Expression Differences in Prostatic Adenocarsinomas

Abstract

AbstractObjective: The roles of mast cells (MCs) have been demonstrated in various biologic processes in the many tumors. MCs play some roles in tumor progression via increasing angiogenesis. Tryptase and chymase are stored in the mast cell granules. The aim of this study was to investigate the relationship of tryptase and chymase in prostatic adenocarcinomas (PA).Materials and Methods: This study was conducted on a total of 134 paraffin-embedded PA samples, which were histopathologically diagnosed at the Department of Pathology of medicine Hospital between 2012 and 2014. Paraffin-embedded PA samples 3 μm in thickness, were then cut. The slides were stained with tryptase and chymase.Result: Mast Cell Chymase (MCC) was observed that intratumoral areas more acumulate than peritumoral areas (respectively; mean: 14,28 ± 14,06, mean: 12,12 ± 12,56). Mast Cell Tryptase (MCT) was more acumulated than MCC in intratumoral and peritumoral areas (P lt;0,001). MCT was observed that peritumoral areas more acumulate than intratumoral areas (respectively; mean: 33,94 ± 20,09, mean: 33,50 ± 18,65). MCT and MCC compared with regard to intratumoral area and peritumoral area. There wasn’t significant difference with MCT (p=0.723). However, MCC was found intratumoral area more than peritumoral area (p=0.007). Conclusion: Mast cells may play an important role for PA. MCC might be more important than MCT in malignant progression.

Keywords

• triptaz
• kimaz
• prostatik adenokarsinomlar
• tryptase
• chymase
• prostatic adenocarcinomas