Nature Communications (Sep 2019)

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

  • Lei Ji,
  • Bo Lu,
  • Raffaella Zamponi,
  • Olga Charlat,
  • Robert Aversa,
  • Zinger Yang,
  • Frederic Sigoillot,
  • Xiaoping Zhu,
  • Tiancen Hu,
  • John S. Reece-Hoyes,
  • Carsten Russ,
  • Gregory Michaud,
  • Jan S. Tchorz,
  • Xiaomo Jiang,
  • Feng Cong

DOI
https://doi.org/10.1038/s41467-019-12143-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Axin is a scaffolding protein known for its role in Wnt signalling that can be marked with a variety of post-translational modifications. Here, Cong et al. demonstrate that USP7 de-ubiquinates Axin and that canonical Wnt signaling output can be increased with USP7 inhibitors.