Primary and Metastatic Pancreatic Ewing Sarcomas: A Case Report and Review of the Literature
Nektarios I. Koufopoulos,
Menelaos G. Samaras,
Christakis Kotanidis,
Konstantinos Skarentzos,
Abraham Pouliakis,
Ioannis Boutas,
Adamantia Kontogeorgi,
Magda Zanelli,
Andrea Palicelli,
Maurizio Zizzo,
Giuseppe Broggi,
Rosario Caltabiano,
Anastasios I. Kyriazoglou,
Dimitrios Goutas
Affiliations
Nektarios I. Koufopoulos
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Menelaos G. Samaras
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Christakis Kotanidis
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Konstantinos Skarentzos
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Abraham Pouliakis
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Ioannis Boutas
Breast Unit, Rea Maternity Hospital, P. Faliro, 17564 Athens, Greece
Adamantia Kontogeorgi
Third Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Magda Zanelli
Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
Andrea Palicelli
Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy
Maurizio Zizzo
Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy
Giuseppe Broggi
Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, 95123 Catania, Italy
Rosario Caltabiano
Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, 95123 Catania, Italy
Anastasios I. Kyriazoglou
Second Propaedeutic Department of Medicine, Oncology Unit, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Dimitrios Goutas
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece
Ewing sarcomas are rare tumors arising mainly in the bones and the surrounding soft tissues. Primary extraosseous Ewing sarcomas have also been described in several other organs and locations other than bones, including the pancreas. These tumors have well-defined histological, immunohistochemical, and molecular characteristics. In this manuscript, we present a case of primary Ewing sarcoma of the pancreas in a 29-year-old patient, and we systematically review the literature on both primary and metastatic Ewing sarcomas of the pancreas, describing their clinicopathological characteristics. We also discuss the differential diagnosis and the treatment of this rare entity.
