Chinese Journal of Lung Cancer (Mar 2009)
Long-term Effect of Chemotherapy of Lung Cancer by Isolated Lung Perfusion and Planted Drug Pump on Pulmonary Artery
Abstract
Background and objective How to treat non-surgical lung cancer effectively is always a great subject in the research and therapy of lung cancer. The aim of this study is to study chemotherapy of lung cancer through isolated lung perfusion (ILP), and to observe the protective efficacy. Methods After high dose of chemotherapy throughcircular perfusion, plant a duct into the inflicted pulmonary artery and lead the duct to a subcutaneous drug pump implanted. Study group of 51 cases was dripped through the pump with ADM, meanwhile dripped drag of GP schedule. Chemo group of 50 cases was applied intravenous GP schedule. Results Disease control rate (CR+PR+SD) is 78.4% instudy group and 56.0% in control group (P =0.016); Survival rate of one year is 81.2% and 23.3% (P <0.001), survival rate of three year is 27.5% and 8.0% (P =0.012), and survival rate of five year is 6.0% and 0 (P =0.240) respectively; Toxin side-effect: ILP had a lesser degree of toxin side-effect, and the side-effect sustained shorter and the recovery was faster; Quality of existence: quality of life in study group was improved obviously. Conclusion ILP is a safe and feasible novelty of treating late lung cancer. The advantage is its high concentration, precise local administration and lesser side-effect; subcutaneous drug pump facilitates the intermittent local administration of drag and could clearly improve the survival rateand life quality.
