In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Wenquan Ou; Samantha Stewart; Alisa White; Elyahb A. Kwizera; Jiangsheng Xu; Yuanzhang Fang; James G. Shamul; Changqing Xie; Suliat Nurudeen; Nikki P. Tirada; Xiongbin Lu; Katherine H. R. Tkaczuk; Xiaoming He

doi:10.1038/s41467-023-36045-7

Nature Communications (Jan 2023)

In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Wenquan Ou,
Samantha Stewart,
Alisa White,
Elyahb A. Kwizera,
Jiangsheng Xu,
Yuanzhang Fang,
James G. Shamul,
Changqing Xie,
Suliat Nurudeen,
Nikki P. Tirada,
Xiongbin Lu,
Katherine H. R. Tkaczuk,
Xiaoming He

Affiliations

Wenquan Ou: Fischell Department of Bioengineering, University of Maryland
Samantha Stewart: Fischell Department of Bioengineering, University of Maryland
Alisa White: Fischell Department of Bioengineering, University of Maryland
Elyahb A. Kwizera: Fischell Department of Bioengineering, University of Maryland
Jiangsheng Xu: Fischell Department of Bioengineering, University of Maryland
Yuanzhang Fang: Department of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine
James G. Shamul: Fischell Department of Bioengineering, University of Maryland
Changqing Xie: Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Suliat Nurudeen: Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Nikki P. Tirada: Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Xiongbin Lu: Department of Medical and Molecular Genetics and Melvin and Bren Simon Cancer Center, Indiana University School of Medicine
Katherine H. R. Tkaczuk: Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Xiaoming He: Fischell Department of Bioengineering, University of Maryland

DOI: https://doi.org/10.1038/s41467-023-36045-7
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

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Cryosurgery can represent a therapeutic option for breast cancer treatment. Here the authors report a strategy combining cryosurgery with cold-responsive nanoparticles loaded with the chemotherapeutic drug irinotecan and PD-L1-targeting siRNA, inducing anti-tumor immune responses in preclinical breast cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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