NeuroImage (Jan 2020)
Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis
- Joanes Grandjean,
- Carola Canella,
- Cynthia Anckaerts,
- Gülebru Ayrancı,
- Salma Bougacha,
- Thomas Bienert,
- David Buehlmann,
- Ludovico Coletta,
- Daniel Gallino,
- Natalia Gass,
- Clément M. Garin,
- Nachiket Abhay Nadkarni,
- Neele S. Hübner,
- Meltem Karatas,
- Yuji Komaki,
- Silke Kreitz,
- Francesca Mandino,
- Anna E. Mechling,
- Chika Sato,
- Katja Sauer,
- Disha Shah,
- Sandra Strobelt,
- Norio Takata,
- Isabel Wank,
- Tong Wu,
- Noriaki Yahata,
- Ling Yun Yeow,
- Yohan Yee,
- Ichio Aoki,
- M. Mallar Chakravarty,
- Wei-Tang Chang,
- Marc Dhenain,
- Dominik von Elverfeldt,
- Laura-Adela Harsan,
- Andreas Hess,
- Tianzi Jiang,
- Georgios A. Keliris,
- Jason P. Lerch,
- Andreas Meyer-Lindenberg,
- Hideyuki Okano,
- Markus Rudin,
- Alexander Sartorius,
- Annemie Van der Linden,
- Marleen Verhoye,
- Wolfgang Weber-Fahr,
- Nicole Wenderoth,
- Valerio Zerbi,
- Alessandro Gozzi
Affiliations
- Joanes Grandjean
- Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore; Corresponding author. Department of Radiology and Nuclear Medicine & Donders Institute for Brain, Cognition, and Behaviour, Donders Institute, Radboud University Medical Centre, Nijmegen, 6525 EZ, the Netherlands.
- Carola Canella
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy; CIMeC, Centre for Mind/Brain Sciences, University of Trento, 38068, Rovereto, Italy
- Cynthia Anckaerts
- Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium
- Gülebru Ayrancı
- Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
- Salma Bougacha
- Commissariat à l’Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France
- Thomas Bienert
- Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany
- David Buehlmann
- Institute for Biomedical Engineering, University and ETH Zürich, Wolfgang-Pauli-Str. 27, 8093, Zürich, Switzerland
- Ludovico Coletta
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy; CIMeC, Centre for Mind/Brain Sciences, University of Trento, 38068, Rovereto, Italy
- Daniel Gallino
- Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
- Natalia Gass
- Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- Clément M. Garin
- Commissariat à l’Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France
- Nachiket Abhay Nadkarni
- Commissariat à l’Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France
- Neele S. Hübner
- Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany
- Meltem Karatas
- Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; The Engineering Science, Computer Science and Imaging Laboratory (ICube), Department of Biophysics and Nuclear Medicine, University of Strasbourg and University Hospital of Strasbourg, 67000, Strasbourg, France
- Yuji Komaki
- Central Institute for Experimental Animals (CIEA), 3-25-12, Tonomachi, Kawasaki, Kanagawa, 210-0821, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
- Silke Kreitz
- Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany
- Francesca Mandino
- Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
- Anna E. Mechling
- Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany
- Chika Sato
- Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan
- Katja Sauer
- Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany
- Disha Shah
- Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium; Laboratory for the Research of Neurodegenerative Diseases, VIB Center for Brain and Disease Research, KU Leuven, O&N4 Herestraat 49 Box 602, 3000, Leuven, Belgium
- Sandra Strobelt
- Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany
- Norio Takata
- Central Institute for Experimental Animals (CIEA), 3-25-12, Tonomachi, Kawasaki, Kanagawa, 210-0821, Japan; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
- Isabel Wank
- Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany
- Tong Wu
- Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Centre for Medical Image Computing, Department of Computer Science, & Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, UK; Computational, Cognitive and Clinical Imaging Lab, Division of Brain Sciences, Department of Medicine, Imperial College London, W12 0NN, UK; UK DRI Centre for Care Research and Technology, Imperial College London, W12 0NN, UK
- Noriaki Yahata
- Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan
- Ling Yun Yeow
- Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore
- Yohan Yee
- Hospital for Sick Children and Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada
- Ichio Aoki
- Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan
- M. Mallar Chakravarty
- Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada
- Wei-Tang Chang
- Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore
- Marc Dhenain
- Commissariat à l’Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France
- Dominik von Elverfeldt
- Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany
- Laura-Adela Harsan
- The Engineering Science, Computer Science and Imaging Laboratory (ICube), Department of Biophysics and Nuclear Medicine, University of Strasbourg and University Hospital of Strasbourg, 67000, Strasbourg, France
- Andreas Hess
- Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany
- Tianzi Jiang
- Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China
- Georgios A. Keliris
- Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium
- Jason P. Lerch
- Hospital for Sick Children and Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, UK
- Andreas Meyer-Lindenberg
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany
- Hideyuki Okano
- Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan; Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan
- Markus Rudin
- Institute for Biomedical Engineering, University and ETH Zürich, Wolfgang-Pauli-Str. 27, 8093, Zürich, Switzerland; Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland
- Alexander Sartorius
- Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- Annemie Van der Linden
- Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium
- Marleen Verhoye
- Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium
- Wolfgang Weber-Fahr
- Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- Nicole Wenderoth
- Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland
- Valerio Zerbi
- Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland
- Alessandro Gozzi
- Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy
- Journal volume & issue
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Vol. 205
p. 116278
Abstract
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and to investigate the determinants of altered network signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison of 17 mouse rsfMRI datasets via a common image processing and analysis pipeline. Despite prominent cross-laboratory differences in equipment and imaging procedures, we report the reproducible identification of several large-scale resting-state networks (RSN), including a mouse default-mode network, in the majority of datasets. A combination of factors was associated with enhanced reproducibility in functional connectivity parameter estimation, including animal handling procedures and equipment performance. RSN spatial specificity was enhanced in datasets acquired at higher field strength, with cryoprobes, in ventilated animals, and under medetomidine-isoflurane combination sedation. Our work describes a set of representative RSNs in the mouse brain and highlights key experimental parameters that can critically guide the design and analysis of future rodent rsfMRI investigations.
