Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Thomas E. Bartlett; Kantaraja Chindera; Jacqueline McDermott; Charles E. Breeze; William R. Cooke; Allison Jones; Daniel Reisel; Smita T. Karegodar; Rupali Arora; Stephan Beck; Usha Menon; Louis Dubeau; Martin Widschwendter

doi:10.1038/ncomms11620

Nature Communications (May 2016)

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Thomas E. Bartlett,
Kantaraja Chindera,
Jacqueline McDermott,
Charles E. Breeze,
William R. Cooke,
Allison Jones,
Daniel Reisel,
Smita T. Karegodar,
Rupali Arora,
Stephan Beck,
Usha Menon,
Louis Dubeau,
Martin Widschwendter

Affiliations

Thomas E. Bartlett: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Kantaraja Chindera: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Jacqueline McDermott: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Charles E. Breeze: Department of Medical Genomics, UCL Cancer Institute, University College London
William R. Cooke: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Allison Jones: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Daniel Reisel: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Smita T. Karegodar: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Rupali Arora: Department of Pathology, UCL Cancer Institute, University College London
Stephan Beck: Department of Medical Genomics, UCL Cancer Institute, University College London
Usha Menon: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London
Louis Dubeau: Department of Pathology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California
Martin Widschwendter: Department of Women’s Cancer, UCL Elizabeth Garrett Anderson Institute for Women’s Health, University College London

DOI: https://doi.org/10.1038/ncomms11620
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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