Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis

Jayhun Lee; Sangjo Kang; Karin C. Lilja; Keegan J. Colletier; Cornelia Johanna Franziska Scheitz; Ying V. Zhang; Tudorita Tumbar

doi:10.1038/ncomms11278

Nature Communications (Apr 2016)

Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis

Jayhun Lee,
Sangjo Kang,
Karin C. Lilja,
Keegan J. Colletier,
Cornelia Johanna Franziska Scheitz,
Ying V. Zhang,
Tudorita Tumbar

Affiliations

Jayhun Lee: Department of Molecular Biology and Genetics, Cornell University
Sangjo Kang: Department of Molecular Biology and Genetics, Cornell University
Karin C. Lilja: Department of Molecular Biology and Genetics, Cornell University
Keegan J. Colletier: Department of Molecular Biology and Genetics, Cornell University
Cornelia Johanna Franziska Scheitz: Department of Molecular Biology and Genetics, Cornell University
Ying V. Zhang: Department of Molecular Biology and Genetics, Cornell University
Tudorita Tumbar: Department of Molecular Biology and Genetics, Cornell University

DOI: https://doi.org/10.1038/ncomms11278
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Changes in global histone trimethylation have been linked to embryonic but not adult stem cell plasticity. Here, Lee et al. find H3 K4/K9/K27me3 levels actively reduced in adult mouse skin and hair follicle stem cells during quiescence (catagen) and link this to active bone morphogen protein signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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