Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL‑1 with Antitumor Activity

• Qineng Gong,
• Chunpu Li,
• Haojie Wang,
• Jinrui Cao,
• Zuo Li,
• Mi Zhou,
• Yan Li,
• Yong Chu,
• Hong Liu,
• Renxiao Wang

Affiliations

Qineng Gong

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Chunpu Li

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Haojie Wang

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Jinrui Cao

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Zuo Li

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Mi Zhou

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Yan Li

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Yong Chu

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China

Hong Liu

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Renxiao Wang

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People’s Republic of China