Infection and Drug Resistance (Jan 2024)
Efficacy and Influencing Factors of Sangju Cough Mixture in the Adjuvant Treatment of Adult Patients with Mycoplasma pneumoniae Infection: A Retrospective Study
Abstract
Xiaoming Yang,* Zhongda Liu,* Xiaojing Liu, Quan Li, Hui Huang, Zunjing Zhang Department of Respiratory and Critical Care Medicine, Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine, Lishui, 323000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zunjing Zhang, No. 800 Zhongshan Road, Liandu District, Lishui, Zhejiang Province, People’s Republic of China, Tel +8613884387661, Email [email protected]: Sangju-Yin, supplemented with some drugs, has frequently demonstrated therapeutic efficacy against colds, albeit its effect on Mycoplasma pneumoniae (MP) infection remains unknown. Therefore, we aimed to elucidate the treatment efficacy and influencing factors of a Sangju cough mixture on MP infection in adults.Patients and Methods: Between January 2021 and December 2022, 150 adult patients with MP infection at the Lishui Hospital of Traditional Chinese Medicine Affiliated with Zhejiang University of Traditional Chinese Medicine were assigned to the treatment (administered Sangju cough mixture and moxifloxacin tablets) or the control (administered moxifloxacin tablets) groups.Results: When compared with the control group, the treatment group exhibited significantly improved traditional Chinese medicine syndrome scores, increased CD4+ T cell levels, and decreased CD8+ T cell levels (all P 0.05); however, after 14 days of treatment, the rate was significantly higher in the treatment group (P 0.05).Conclusion: Sangju cough mixture can improve symptoms, accelerate the negative conversion time of MP-IgM antibody, and promote rehabilitation of the patients.Keywords: Mycoplasma pneumoniae infection, Sangju cough mixture, moxifloxacin, negative conversion time, influencing factors
