Beilstein Journal of Organic Chemistry (Apr 2009)

Oxidative cyclization of alkenols with Oxone using a miniflow reactor

  • Yoichi M. A. Yamada,
  • Kaoru Torii,
  • Yasuhiro Uozumi

DOI
https://doi.org/10.3762/bjoc.5.18
Journal volume & issue
Vol. 5, no. 1
p. 18

Abstract

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A miniflow system for oxidative cyclization of alkenols with Oxone was developed. Thus, the oxidative cyclization of (Z)- and (E)-alkenols in i-PrOH with an aqueous solution of Oxone proceeded smoothly and safely in a PTFE tube without any exogenous catalytic species, and was subsequently quenched in a flow-reaction manner to afford the corresponding furanyl and pyranyl carbinols quantitatively within 5 or 10 min of residence time.

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