Frontiers in Oncology (Jul 2021)

Long-Term Surgical Outcomes of Liver Resection for Hepatocellular Carcinoma in Patients With HBV and HCV Co-Infection: A Multicenter Observational Study

  • Hang-Dong Jia,
  • Hang-Dong Jia,
  • Lei Liang,
  • Lei Liang,
  • Chao Li,
  • Han Wu,
  • Hong Wang,
  • Ying-Jian Liang,
  • Ya-Hao Zhou,
  • Wei-Min Gu,
  • Xin-Ping Fan,
  • Wan-Guang Zhang,
  • Ting-Hao Chen,
  • Zhi-Yu Chen,
  • Jian-Hong Zhong,
  • Wan Yee Lau,
  • Wan Yee Lau,
  • Timothy M. Pawlik,
  • Yong-Kang Diao,
  • Yong-Kang Diao,
  • Qiu-Ran Xu,
  • Qiu-Ran Xu,
  • Feng Shen,
  • Cheng-Wu Zhang,
  • Dong-Sheng Huang,
  • Dong-Sheng Huang,
  • Tian Yang,
  • Tian Yang,
  • Tian Yang

DOI
https://doi.org/10.3389/fonc.2021.700228
Journal volume & issue
Vol. 11

Abstract

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BackgroundHepatocellular carcinoma (HCC) is one of the most serious consequences of chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. This study sought to investigate long-term outcomes after liver resection for HCC among patients with HBV/HCV co-infection (HBV/HCV-HCC) compared with patients with HBV infection (HBV-HCC).MethodsPatients who underwent curative-intent liver resection for HCC were identified from a multicenter Chinese database. Using propensity score matching (PSM), patients with HBV/HCV-HCC were matched one-to-one to patients with HBV-HCC. Overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups before and after PSM.ResultsAmong 2,467 patients identified, 93 (3.8%) and 2,374 (96.2%) patients had HBV/HCV-HCC and HBV-HCC, respectively. Compared with patients with HBV-HCC, patients with HBV/HCV-HCC were older, have poorer liver-related characteristics but better tumor-related characteristics. PSM created 88 pairs of patients with comparable liver- and tumor-related characteristics (all P > 0.2). In the PSM cohort, the 3- and 5-year RFS rates in patients with HBV/HCV-HCC were 48.3% and 38.9%, which were significantly poorer than patients with HBV-HCC (61.8% and 49.2%, P = 0.037). Meanwhile, the 3- and 5-year OS rates in patients with HBV/HCV-HCC were also poorer than patients with HBV-HCC (65.4% and 51.1% vs. 73.7% and 63.0%), with a difference close to be significant between them (P = 0.081).ConclusionComparing to patients with HBV-HCC, liver resection resulted in relatively poorer long-term surgical outcomes in patients with HBV/HCV-HCC.

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