Nature Communications (Dec 2022)
Nasal DNA methylation at three CpG sites predicts childhood allergic disease
- Merlijn van Breugel,
- Cancan Qi,
- Zhongli Xu,
- Casper-Emil T. Pedersen,
- Ilya Petoukhov,
- Judith M. Vonk,
- Ulrike Gehring,
- Marijn Berg,
- Marnix Bügel,
- Orestes A. Carpaij,
- Erick Forno,
- Andréanne Morin,
- Anders U. Eliasen,
- Yale Jiang,
- Maarten van den Berge,
- Martijn C. Nawijn,
- Yang Li,
- Wei Chen,
- Louis J. Bont,
- Klaus Bønnelykke,
- Juan C. Celedón,
- Gerard H. Koppelman,
- Cheng-Jian Xu
Affiliations
- Merlijn van Breugel
- University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Department of Pediatric Pulmonology and Pediatric Allergology
- Cancan Qi
- University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Department of Pediatric Pulmonology and Pediatric Allergology
- Zhongli Xu
- Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh
- Casper-Emil T. Pedersen
- COPSAC (Copenhagen Prospective Study on Asthma in Childhood), Herlev and Gentofte Hospital
- Ilya Petoukhov
- MIcompany
- Judith M. Vonk
- University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC)
- Ulrike Gehring
- Institute for Risk Assessment Sciences, Utrecht University
- Marijn Berg
- University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC)
- Marnix Bügel
- MIcompany
- Orestes A. Carpaij
- University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC)
- Erick Forno
- Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh
- Andréanne Morin
- Department of Human Genetics, University of Chicago
- Anders U. Eliasen
- COPSAC (Copenhagen Prospective Study on Asthma in Childhood), Herlev and Gentofte Hospital
- Yale Jiang
- Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh
- Maarten van den Berge
- University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC)
- Martijn C. Nawijn
- University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC)
- Yang Li
- Centre for Individualized Infection Medicine (CiiM), a joint venture between Hannover Medical School and Helmholtz Centre for Infection Research
- Wei Chen
- Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh
- Louis J. Bont
- Department of Pediatrics, Wilhelmina Children’s Hospital, University Medical Centre Utrecht
- Klaus Bønnelykke
- COPSAC (Copenhagen Prospective Study on Asthma in Childhood), Herlev and Gentofte Hospital
- Juan C. Celedón
- Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh
- Gerard H. Koppelman
- University of Groningen, University Medical Center Groningen, Beatrix Children’s Hospital, Department of Pediatric Pulmonology and Pediatric Allergology
- Cheng-Jian Xu
- Centre for Individualized Infection Medicine (CiiM), a joint venture between Hannover Medical School and Helmholtz Centre for Infection Research
- DOI
- https://doi.org/10.1038/s41467-022-35088-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Accurate prediction of the onset of childhood allergy is important to clarify the difference between various respiratory diseases. Here the authors propose that the methylation status of three sites in nasal DNA predicts the onset of childhood allergy which may aid diagnosis and monitoring.
