Dose-Response (Jul 2022)

Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer

  • Ana Jotic Ph.D., M.D.,
  • Jovica Milovanovic Ph.D., M.D.,
  • Katarina Savic-Vujovic Ph.D., M.D.,
  • Zorana Radin M.D.,
  • Branislava Medic Ph.D., M.D.,
  • Miljan Folic Ph.D., M.D.,
  • Bojan Pavlovic Ph.D., M.D.,
  • Aleksandar Vujovic M.D.,
  • Dusko Dundjerovic Ph.D., M.D.

DOI
https://doi.org/10.1177/15593258221115537
Journal volume & issue
Vol. 20

Abstract

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Objective The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. Material and Methods A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. Results Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4 + and CD8 + were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. Conclusion Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma.